The Research Progress of Retinoic Acid in Endometriosis

doi:10.12280/gjfckx.20210358

Abstract

Abstract:

Endometriosis (EMs) is a common gynecological benign disease that seriously affects the quality of life and fertility of women. Its complex pathophysiological mechanism has not been clear. Despite the continuous improvement in diagnostic criteria and treatment protocols of EMs, the high incidence rate and low cure rate did not improve significantly. Retinoic acid (RA), as an active metabolite of vitamin A, is involved in various cell growth, differentiation and organogenesis processes. RA is abnormally low in EMs due to metabolic defects, and a large number of studies have shown that RA signal defects may participate in the occurrence of EMs by increasing local endometrial estrogen levels, inhibiting apoptosis and autophagy, pro-inflammatory and abnormal immune regulation, etc. Therefore, RA and its derivatives are expected to become new drugs for the treatment of EMs. The abnormal metabolism of RA in EMs, the possible mechanisms by which RA signal defects promote the occurrence and development of EMs, and the therapeutic potential of RA in EMs are reviewed in order to provide new ideas for the pathogenesis and treatment of EMs.

Key words: Tretinoin, Endometriosis, Estrogens, Autophagy, Inflammation, Immunity, Therapy

LI Qian-qian, TANG Xiao-han, LU Mei-song. The Research Progress of Retinoic Acid in Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2021, 48(6): 696-699.

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