Research Progress of NF-κB in the Pathogenesis of Pre-Eclampsia

doi:10.12280/gjfckx.20210595

Abstract

Abstract:

Pre-eclampsia is one of the main causes of maternal morbidity in the world. At present, it may be related to insufficient recasting of uterine spiral arterioles, excessive activation of inflammation and immunity, damage of endothelial vascular cells, and so on. Recent studies have shown that microparticle can increase the expression of NF-κB in patients with pre-eclampsia, and promote the formation of neutrophil extracellular trap, resulting in inflammation at the maternal-fetal interface and vascular endothelial cell dysfunction, and participate in the pathophysiological process of pre-eclampsia.

Key words: Pre-eclampsia, NF-kappa B, Cell-derived microparticles, Inflammation, Extracellular traps

ZHAO Yu-lin, WANG Yong-hong. Research Progress of NF-κB in the Pathogenesis of Pre-Eclampsia[J]. Journal of International Obstetrics and Gynecology, 2022, 49(1): 56-59.

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