Research Progress of Elabela in Pre-Eclampsia

doi:10.12280/gjfckx.20210746

Abstract

Abstract:

Pre-eclampsia is one of the main causes of maternal and neonatal death. At present, the pathogenesis is still unclear. Elabela is a newly discovered endogenous peptide ligand of Apelin receptor (APJ). Elabela and Apelin have a small number of similar sequences, showing similar biological effects, which are involved in many kinds of human diseases, such as acute kidney injury, heart failure, diabetes, hypertension, fetal dysplasia, tumor and so on. Compared with Apelin, the first ligand of APJ, Elabela can be detected in maternal serum, placenta, urine and fetal umbilical cord blood. Elabela participates in the formation of embryonic cardiovascular system and the early development of placenta, and plays a key role in the pathogenesis of pre-eclampsia. In this review, we summarize the structure and biological function of Elabela and its relationship with the pathogenesis of pre-eclampsia, and discusses the possible mechanism of Elabela′s involvement in the pathogenesis of pre-eclampsia, including the invasion of placental trophoblast, angiogenesis and damage to maternal vascular endothelial cells.

Key words: Pre-eclampsia, Hypertension, Receptor,angiotensin,type 1, Placenta, Neovascularization,physiologic, Elabela

WANG Li-jing, WANG Fu-rong, SUN Xian-li, LI Yuan-mei, DONG Rui-feng. Research Progress of Elabela in Pre-Eclampsia[J]. Journal of International Obstetrics and Gynecology, 2022, 49(2): 121-124.

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