Abstract:

Retrospective analysis of a case of pregnancy complicated with cervical large cell neuroendocrine carcinoma stage ⅢC1(r) cesarean section after intravenous chemotherapy occurred hyponatremia. Chemotherapy and radiation were employed to treat the main tumor, and symptomatic treatment was utilized to deal with hyponatremia. After 6 months of complete remission, there was a recurrence of the disease. Through the chemotherapy combined with targeted and immunotherapy, the patient experienced distributed shock and electrolyte disorder, and the patient′s family to give up the treatment. The follow-up didn′t break off until the patient died in May 2023. The prognosis for cervical large cell neuroendocrine carcinoma is poor due to its high level of aggressiveness. Hyponatremia may be associated with a poor prognosis of the tumor, which in clinical practice is easily obscured by severe effects to chemotherapy in the clinic. Understanding the clinical signs of hyponatremia, improve the ability of early recognition, obtaining an early diagnosis and course of therapy, and actively enhancing patient prognosis are all important for clinicians.

Key words: Uterine cervical neoplasms, Carcinoma, neuroendocrine, Hyponatremia, Inappropriate ADH syndrome, Prognosis