Research Progress on the Influence of Maternal Metabolism and Gestational Nutrition on Gut Microbiota

doi:10.12280/gjfckx.20250439

Abstract

Abstract:

The influence of gestational nutrition on the maternal gut microbiota and fetal development is a hot-topic in clinical research. Increasing attention has been paid to the impact of the maternal internal environment on fetal development and the long-term health of offspring. Traditionally, it was believed that fetal development was mainly dominated by genetic programs. However, studies have shown that the fetus has complex perception and learning abilities, and the maternal nutritional and metabolic status is a key factor determining the health of offspring. Based on the "thrifty phenotype hypothesis", intrauterine malnutrition in the fetus can increase the risk of metabolic diseases in adulthood through metabolic reprogramming. Gestational nutrition has a profound impact on fetal developmental programming and the long-term health of offspring by reshaping the gut microbiota and its metabolite profile. This review summarizes the dynamic changes in gut microbiota during pregnancy, the hormonal and immune regulatory mechanisms, and the effects of different dietary patterns on the gut microbiota and the health of mothers and infants.

Key words: Pregnant women, Gastrointestinal microbiome, Microbiota, Prenatal nutritional physiological phenomena, Metabolism

ZHAO Xiao-wei, JIANG Lu. Research Progress on the Influence of Maternal Metabolism and Gestational Nutrition on Gut Microbiota[J]. Journal of International Obstetrics and Gynecology, 2025, 52(5): 563-566.

References 31

[1]	Nobile S, Di Sipio Morgia C, Vento G. Perinatal Origins of Adult Disease and Opportunities for Health Promotion: A Narrative Review[J]. J Pers Med, 2022, 12(2):157. doi: 10.3390/jpm12020157.
[2]	Barker DJ. Developmental origins of adult health and disease[J]. J Epidemiol Community Health, 2004, 58(2):114-115. doi: 10.1136/jech.58.2.114.
[3]	Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis[J]. Diabetologia, 1992, 35(7):595-601. doi: 10.1007/BF00400248. pmid: 1644236
[4]	戴丽萍, 王雅君, 张玉梅. 营养干预在妊娠期代谢综合征中的应用进展[J]. 医学综述, 2023, 29(20):4212-4216. doi: 10.3969/j.issn.1006-2084.2023.20.035.
[5]	Pronovost GN, Yu KB, Coley-O'Rourke E, et al. The maternal microbiome promotes placental development in mice[J]. Sci Adv, 2023, 9(40):eadk1887. doi: 10.1126/sciadv.adk1887.
[6]	Liang W, Feng Y, Yang D, et al. Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus[J]. Mol Med, 2023, 29(1):122. doi: 10.1186/s10020-023-00716-4. pmid: 37684563
[7]	Ma Y, Liu T, Li X, et al. Estrogen receptor β deficiency impairs gut microbiota: a possible mechanism of IBD-induced anxiety-like behavior[J]. Microbiome, 2022, 10(1):160. doi: 10.1186/s40168-022-01356-2. pmid: 36175956
[8]	闫丽, 王恺悦, 王喜良, 等. 戊酸雌二醇片/雌二醇环丙孕酮片对卵巢早衰小鼠激素水平和肠道菌群的调节作用[J]. 中国医科大学学报, 2023, 52(10):898-903. doi: 10.12007/j.issn.0258-4646.2023.10.006.
[9]	Zhao L, Zhang J, He J, et al. Network pharmacology analysis of the regulatory effects and mechanisms of ALAE on sow reproduction in vivo and in vitro[J]. J Ethnopharmacol, 2024, 334:118525. doi: 10.1016/j.jep.2024.118525.
[10]	冷芹, 于威威, 刘英, 等. 肠道菌群与产科疾病的相关性研究进展[J]. 中国微生态学杂志, 2024, 36(10):1228-1230. doi: 10.13381/j.cnki.cjm.202410017.
[11]	许烨烨, 任丽萍. 不明原因复发性流产免疫稳态平衡及治疗的研究进展[J]. 贵州医药, 2025, 49(1):44-47. doi: 10.3969/j.issn.1000-744X.2025.01.010.
[12]	Raouia F, Mariem BJ, Nesrine E, et al. CD4⁺ T-cell Subsets and Cytokine Signature in Pemphigus Foliaceus Clinical Stratification beyond the th1/Th2 Paradigm[J]. Curr Mol Med, 2025, 25(4):485-495. doi: 10.2174/0115665240305096240611064617.
[13]	崔雍涵, 冯晓玲. 肠道菌群调控下的Th17/Treg细胞失衡与不明原因复发性流产的相关性研究进展[J]. 中国微生态学杂志, 2023, 35(12):1471-1474,1482. doi: 10.13381/j.cnki.cjm.202312020.
[14]	Roy R, Kumar D, Bhattacharya P, et al. Modulating the biosynthesis and TLR4-interaction of lipopolysaccharide as an approach to counter gut dysbiosis and Parkinson's disease: Role of phyto-compounds[J]. Neurochem Int, 2024, 178:105803. doi: 10.1016/j.neuint.2024.105803.
[15]	Koren O, Konnikova L, Brodin P, et al. The maternal gut microbiome in pregnancy: implications for the developing immune system[J]. Nat Rev Gastroenterol Hepatol, 2024, 21(1):35-45. doi: 10.1038/s41575-023-00864-2. pmid: 38097774
[16]	Williams K, Fryer A, Jacoby D, et al. Maternal High-Fat Diet Programs Development of Airway Hyperinnervation and Hyperresponsiveness In Offspring Independent of Genetic Background[J]. Physiol, 2024, 39(S1):3-9. doi: 10.1152/physiol.2024.39.S1.1391.
[17]	Rousseau-Ralliard D, Chavatte-Palmer P, Couturier-Tarrade A. Importance of maternal exposure windows to high-fat diet on placental function and phenotype of the offspring: Summary review of work carried out in rabbit[J]. Cahiers de nutrition et de dietetique, 2024, 23(2):59. doi: 10.1016/j.cnd.2023.12.002.
[18]	Gonzalez K, Merlin AC, Roye E, et al. Voluntary Wheel Running Reduces Cardiometabolic Risks in Female Offspring Exposed to Lifelong High-Fat, High-Sucrose Diet[J]. Med Sci Sports Exerc, 2024, 56(8):1378-1389. doi: 10.1249/MSS.0000000000003443.
[19]	Hao J, Jin X, Li Z, et al. Anti-Obesity Activity of Sanghuangporus vaninii by Inhibiting Inflammation in Mice Fed a High-Fat Diet[J]. Nutrients, 2024, 16(13):2159. doi: 10.3390/nu16132159.
[20]	Somi Sankaran P. High-fat-diet induced obesity and diabetes mellitus in Th1 and Th2 biased mice strains: A brief overview and hypothesis[J]. Chronic Dis Transl Med, 2023, 9(1):14-19. doi: 10.1002/cdt3.57.
[21]	卢星宇, 徐一丹, 刘亦沁, 等. 高脂饮食对孕期小鼠脂肪组织构成和炎症特征的影响[J]. 上海交通大学学报(医学版), 2024, 44(8):981-990. doi: 10.3969/j.issn.1674-8115.2024.08.007.
[22]	Tung K, Wong RS, Mak R. Maternal n-3 PUFA Intake During Pregnancy and Perinatal Mental Health Problems: A Systematic Review of Recent Evidence[J]. Curr Nutr Rep, 2023, 12(3):426-438. doi: 10.1007/s13668-023-00484-x.
[23]	Sakayori N, Fujii K, Katakura M, et al. Mice Born to Mothers Fed a Diet High in Omega-6 Fatty Acids and Low in Omega-3 Fatty Acids During Pregnancy Exhibit Various Behavioral Changes Including Impaired Social Behaviors and Enhanced Recognition Memory[J]. J Nutr, 2025, 155(3):775-787. doi: 10.1016/j.tjnut.2024.12.031.
[24]	Jyesta P, Oroszi T. Obesity and Pregnancy as Risk Factors for Influenza and Pneumonia[J]. Health, 2024, 16(12):11-19. doi: 10.4236/health.2024.1612090.
[25]	Lu H, Wu J, Cheng Q, et al. Dietary fiber consumption by sows during pregnancy has effects on gut microbial composition and immunity of offspring[J]. Anim Prod Sci, 2024, 64(17):34-41. doi:10.1071/AN24077.
[26]	Liu X, Wei X, Feng Y, et al. Supplementation with Complex Dietary Fiber during Late Pregnancy and Lactation Can Improve Progeny Growth Performance by Regulating Maternal Antioxidant Status and Milk Quality[J]. Antioxidants(Basel), 2023, 13(1):22. doi: 10.3390/antiox13010022.
[27]	Guo D, Ning X, Bai T, et al. Interaction between Vitamin D homeostasis, gut microbiota, and central precocious puberty[J]. Front Endocrinol(Lausanne), 2024, 15:1449033. doi: 10.3389/fendo.2024.1449033.
[28]	Kacimi FE, Ed-Day S, Didou L, et al. Narrative Review: The Effect of Vitamin A Deficiency on Gut Microbiota and Their Link with Autism Spectrum Disorder[J]. J Diet Suppl, 2024, 21(1):116-134. doi: 10.1080/19390211.2023.2179154.
[29]	Xiang L, Du T, Zhang J, et al. Vitamin D3 supplementation shapes the composition of gut microbiota and improves some obesity parameters induced by high-fat diet in mice[J]. Eur J Nutr, 2024, 63(1):155-172. doi: 10.1007/s00394-023-03246-1.
[30]	Sohrabi R, Mousavi SN, Shapouri R, et al. The gut dysbiosis of mothers with gestational diabetes and its correlation with diet[J]. Sci Rep, 2025, 15(1):18566. doi: 10.1038/s41598-025-03767-1.
[31]	Qiu J, Hu P, Li F, et al. Circulating linoleic acid and its interplay with gut microbiota during pregnancy for gestational diabetes mellitus[J]. BMC Med, 2025, 23(1):245. doi: 10.1186/s12916-025-04061-7.