Research Progress on the Anti-Gynecological Malignancy Effects of Chinese Herbal Polysaccharides

doi:10.12280/gjfckx.20250700

Abstract

Abstract:

The incidence and mortality rates of gynecological malignancies are increasing year by year, posing a serious threat to women′s health. Traditional Chinese medicine is widely used in the comprehensive treatment of gynecological malignancies. As the most common active components of traditional Chinese medicine, the mechanisms of Chinese herbal polysaccharides against gynecological malignancies include regulating tumor-related signaling pathways, arresting the tumor cell cycle, inhibiting tumor cell metastasis and invasion, promoting tumor cell apoptosis, autophagy and ferroptosis, suppressing tumor cell immune escape and epithelial-mesenchymal transition, regulating the expression of oncogenes and tumor suppressor genes, and serving as efficient drug carriers to reduce toxicity and enhance efficacy. However, the clinical application of traditional Chinese medicine polysaccharides still faces challenges such as low bioavailability and complex separation and extraction. In the future, it is necessary to conduct further basic research and clinical trials to provide references for the development of innovative traditional Chinese medicine and promote the wide clinical application of the combination of traditional Chinese and Western medicine in the treatment of gynecological malignancies.

Key words: Polysaccharides, Chemical compositions (TCD), Uterine cervical neoplasms, Ovarian neoplasms, Endometrial neoplasms

GAO Yue, SHI Bai-chao, YU Jian-nan, ZHANG Li-qian, WANG Yu, WU Xiao-ke. Research Progress on the Anti-Gynecological Malignancy Effects of Chinese Herbal Polysaccharides[J]. Journal of International Obstetrics and Gynecology, 2025, 52(6): 685-689.

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