The Role of Chemokines and Their Receptors in the Pathogenesis of Preeclampsia

doi:10.12280/gjfckx.20251239

Abstract

Abstract:

Preeclampsia (PE) is a severe and highly prevalent pregnancy complication with a complex pathogenesis involving multiple pathological processes. Studies have demonstrated that the expression levels and functions of certain specific chemokines and their receptors are significantly different between pregnant women with PE and normal pregnant women. These abnormalities can be cooperatively regulated through multiple signaling pathways, disrupting the immune tolerance homeostasis at the maternal-fetal interface and inducing local immune microenvironment disturbances. Simultaneously, they interfere with normal placental vascular development and remodeling, and significantly inhibit the migration, invasion and infiltration capabilities of trophoblast cells. Consequently, they contribute to impaired spiral artery remodeling, placental hypoperfusion and ischemic-hypoxic injury, excessive activation of systemic inflammatory responses, and vascular endothelial dysfunction, ultimately participating in and mediating the onset and progression of PE. This review summarizes recent research advances regarding the role of chemokines and their receptors in the pathogenesis of PE, aiming to provide a theoretical basis and new insights for the diagnosis and treatment of PE.

Key words: Inflammatory chemokines, Receptors, chemokine, Pre-eclampsia, Maternal-fetal interface, Immune regulation

CAO Ru, HE Bi-wei, YANG Xing-yu, LIANG Shu-zhen, CHENG Wei-wei. The Role of Chemokines and Their Receptors in the Pathogenesis of Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2026, 53(3): 241-248.

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