Journal of International Obstetrics and Gynecology ›› 2014, Vol. 41 ›› Issue (4): 390-394.

• 综述 • Previous Articles     Next Articles

Relationship between miRNA Regulating Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer

ZHANG Yue,ZHANG Shu   

  1. Department of Obstetrics and Gynecology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University;Shanghai key Laboratory of Gynecologic Oncology, Shanghai 200127,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-08-15 Online:2014-08-15
  • Contact: ZHANG Shu

Abstract: Ovarian cancer is a common gynecological malignancy and one of leading causes of cancer-related morbidity and mortality in female patients around the globe. The metastasis of ovarian cancer is an important factor in causing deaths. EMT (epithelial-mesenchymal transition) refers to the transition process from the phenotype of epithelial cells to mesenchymal phenotype and is closely associated with the malignant progression of tumors in its invasion and metastasis. MicroRNA (miRNA) are a class of small molecule and noncoding RNAs which inhibit translation of the mRNA transcript of the genes expression,and become more and more concerned in regulating EMT progress. Many kinds of miRNA expressed abnormally and related to the occurrence and development of ovarian cancer,are expected to be used in early diagnosis,treatment and prognosis.In this review,we presented recent research regarding the role of EMT and related microRNAs in the malignant progression of ovarian cancer.

Key words: Ovarian neoplasms, Carcinoma, Epithelial-mesenchymal transition, MicroRNAs, Neoplastic stem cells, Neoplasm metastasis