Abstract: Objective： To explore carbetocin in the prevention of postpartum hemorrhage （PPH） following cesarean delivery in women with hypertensive disorder complicating pregnancy. Methods：Prospective randomized control study was carried out on single pregnancy with gestation more than 32 weeks following cesarean delivery. All the cases were randomized to receive either carbetocin （treatment group，n=90） or oxytocin （control group，n=90）. Following delivery of each baby，20 IU oxytocin was infusion and 100 microgram carbetocin（treatment group） and 100 microgram oxytocin（control group） were given as myometrium injection. 24 h blood volume of postpartum，blood pressure，birth weight，Apgar scores，maternal heart rate and drug adverse reaction were collected. Results：The estimated blood loss within 24 h in treatment group was significantly lower than control group（P＜0.05）. The incidence postpartum haemorrhage of treatment and control group had no difference（14.4% vs． 20.0%，P＞0.05）. There was no difference in birth weight，Apgar scores，neonatal asphyxia and amniotic fluid characteristics between the two groups（P＞0.05）. There was no significant syndrome of nausea and vomiting. Conclusions：Carbetocin makes better effect than common oxytocin on prevention of postpartum haemorrhage cesarean delivery in women with hypertensive disorder complicating pregnancy，and no adverse complication was found.

Key words: Oxytocin, Hypertension, pregnancy-induced, Postpartum hemorrhage