Abstract: Cervical intraepithelial neoplasia （CIN） is a precancerous change，which can be divided into grade one，grade two and grade three. The disease should be taken to surgery when the pathologic change is more serious than CINⅠ. But there is still some postoperative recurrence rate. There are plenty of factors affecting the recurrence rate，including positive margins，positive endocervical curettage，reduced immunity，senium and so on. Until now，the relationship between HPV and the recurrence rate is not clear，but it′s confirmed that the persistent infection with HPV must increase the recurrence rate. Furthermore，the load of HPV and subtypes of HPV have played an important role in increasing the rate of CIN recurrence. This paper described the influence of HPV on CIN recurrence.

Key words: Human papillomavirus 16, Cervical intraepithelial neoplasia, Genotype, Recurrence