Abstract: Hydatidiform mole （HM） is a gestational trophoblastic disease （GTD） characterized by proliferation of the pregnancy-associated trophoblastic tissue. With the widespread use of ultrasound, early diagnosis and treatment of hydatidiform mole is possible, but the diagnosis is still based on histopathology. The treatment of hydatidiform mole is difficult, and the prognosis of this disease is not vary good especially in recurrent hydatidiform mole. The mechanism of hydatidiform mole remains unclear. Different type of mole and the wrong chromosome gene imprinting have been found in genetics. Recently, the nucleotide-binding domain, leucine rich containing, pyrin domain containing 7 （NLRP 7） gene is found to connected with recurrent hydatidiform mole. This article will have a review of NLRP 7 gene in the role of hydatidiform mole.

Key words: Hydatidiform mole, Genetics, Mutation, Immunity, NLRP 7 gene