Abstract: Recently, with the popularity of intrauterine operation, the incidence of intrauterine adhesions(IUA) is increasing gradually. Hysteroscopic adhesiolysis has become an effective treatment of IUA. Estrogen use as an perioperative adjuvant therapy has been extensively applied to clinical practice，however the treatment remains empirically based. The purpose of this article was to review the literature to understand changes of endometrium with intrauterine adhesions and to analyze the mechanism and efficacy of estrogen therapy. Furthermore, this article summarized the dose,duration and other treatment strategies of estrogｅｎ，ｗhich provide evidence to use estrogen as perioperative adjuvant therapy in IUA.

Key words: Uterine diseases, Adhesions, Estrogens, Hysteroscopes, Hysteroscopy, Endometrium