Abstract: Cervical cancer is one of the most common gynecological malignant tumors. In recent years, the incidence of cervical cancer has increased year by year, and there is a trend of youth. Cervical intraepithelial neoplasia (CIN) is caused by persistent infection of high risk human papillomavirus (HPV). It is a precancerous lesion of cervical cancer, and it reflects the continuous process of the development of cervical cancer. From the development of CIN to cervical cancer needs a long time. In the progress of CIN, many gene structure and function will change. Recent studies have found that there are some abnormal expression of biological markers between the CIN and cervical cancer tissue, which are related to the level of the precursor and the metastasis of the tumor. These genes as CIN progression of molecular biomarkers for testing to early detect and diagnosis of cervical cancer has become a hot research. In this article, we reviewed the research on the frontier molecular biology of CIN.

Key words: Cervical intraepithelial neoplasia, Uterine cervical neoplasms, Biological markers, Telomerase, Interleukins, Toll-like receptors