Abstract: Objective: To analyze the clinical effect of different treatment regimens of cornual pregnancy and its effect on postoperative fertility. Methods: 95 cases of cornual pregnancy patients admitted in our hospital from January 2012 to December 2015 were retrospectively analyzed. They were divided into 5 groups according to the treatment methods: uterine curettage group (n=21), laparotomy group (n=27), laparoscopic surgery group (n=33), reduction group (n=5), drug treatment group (n=9). To analyze the clinical effect of different treatment regimens and the effect on postoperative fertility. Results: All surgical patients were treated successfully an no adverse reactions occurred after surgery. The bleeding volume in the laparotomy group was the largest and the uterine curettage group was the smallest (P＜0.05). The operation time of the uterine curettage group was shorter than that of laparotomy group and laparoscopic surgery group (P＜0.05), but there was not statistical difference between laparotomy group and laparoscopic surgery group (P＞0.05). The decline of postoperative 3 d β-hCG of uterine curettage group was significantly more than that of laparotomy group and laparoscopic group (P＜0.05). The hospitalization days of uterine curettage group was the shortest and the laparotomy group was the longest (P＜0.05). In the 9 patients of drug treatment group, 8 cases of gestational sac were completely discharged and the discharge time of the gestational sac was 3-5.5 h, averaged (4.1±1.2) h; the vaginal bleeding time was 5-8 d, averaged (7.2±1.4) d. The remaining 1 case treated by uterine curettage due to incomplete miscarriage of labor. After following-up for 1 year after treatment, 5 cases of reduction group delivered successfully. 41 cases in another planned pregnancy 81 cases were intrauterine pregnancy. The re-pregnancy rate in the drug treatment group was the highest and the laparotomy group was the lowest (P＜0.05). Conclusions: In the development of treatment programs, we should give full consideration to the patient′s condition, the size of the gestational sac, the location and whether rupture, the patients′ wishes and physicians′ practical experience and surgical techniques. Minimally invasive surgery is the development trend of cornual pregnancy treatment.

Key words:  Cornual pregnancy, Pregnancy, ectopic, Therapy, Fertility