Abstract: Objective：To investigate the clinical features, diagnosis, treatment and prognosis of intermediate trophoblastic tumors (ITTS), including the placental site trophoblastic tumor (PSTT), epithelioid trophoblastic tumor (ETT). Methods：A restrospective study was performed. Of 8 cases with ITTS. Results：Of the 8 patients, 1 was ETT, 1 coexisting with ETT and PSTT, 6 PSTT. Most of the first symptoms were menopause, irregular vaginal bleeding, abdominal pain, and a slight increase in human chorionic gonadotropin (hCG) with blood, and ITTS was mostly confirmed by pathology. 5 cases were prepared to retain fertility (3 successful, 2  failed), the remaining 3 cases receiving total uterus + double appendage resection, of which 1 cases relapsed, after chemotherapy remission again. Conclusions：The diagnosis of ITTS should be combined with clinical features, pathological and immunohistochemical. The first choice is total hysterectomy. When there are high risk factors, chemotherapy should be combined. For young patients, with strong fertility restriction and limited foci can try to preserve fertility. The factors influencing prognosis of ITTS are not yet clear.

Key words: Gestational trophoblastic neoplasms, Trophoblastic tumor, placental site, Hydatidiform mole, invasive, Fertility