Abstract: Objective：To investigate the clinical diagnosis and treatment progress of malignant Brenner tumor (MBT), analyze its clinical characteristics, and strengthen the understandings of malignant ovarian Brenner tumor. Methods：A case of malignant Brenner tumor at the Second Hospital of Jilin University in September 2017, were analyzed, and the related literatures were reviewed. The progress of diagnosis and treatment was summarized. Results：The patients were confirmed by surgical histopathology and immunohistochemical markers. There was no specific clinical manifestation. Immunohistochemistry was positive for GATA3 (+) and CK7, especially for P53 and P63. Conclusions：The clinical manifestations and imaging manifestations of this disease are unspecific. The diagnosis is based on histopathological and immunohistochemical markers. It is also necessary to distinguish from transitional cell carcinoma. Surgical resection is the main treatment. The standard chemotherapy is carboplatin plus paclitaxel.

Key words: Brenner tumor, Ovarian neoplasms, Diagnosis, differential, Case reports