Clinical Analysis of Human Papillomavirus Infection after Loop Electrosurgical Excision Procedure for Cervical Intraepithelial Neoplasia

Abstract

Abstract: Objective：To assess relevant factors of human papillomavirus infection and prognosis after loop electrosurgical excision procedure (LEEP) in patients with cervical intraepithelial neoplasia (CIN). Methods: A retrospective study was performed with 297 women suffered CIN and treated with LEEP at China Medical University affiliated Shengjing Hospital between Jan 2013 and Dec 2015. Participated in at least one follow-up were analyzed retrospectively. The clinicopathological factors, HPV genotype, postoperation residual and recurrence factors were analyzed. Results: HPV positive rate was 14.5% (43/297) after LEEP. HPV positive was significantly related to margin positive and CIN accompanied with vaginal intraepithelial neoplasia (VAIN) and/or vulval intraepithelial neoplasia (VIN) (P＜0.05). 69.8% (30/43) of HPV positive was at first visit after LEEP. 30.2% (13/43) of HPV positive was occurred after turning negative. The positive rate of high-risk HPV after LEEP was significantly correlated with the residual or recurrence of lesions (r=0.401, P＝0.000). The risk of persistent infection of the same type of HPV before and after operation was significantly higher than that of different types of HPV infection (χ2=5.619, P＝0.046). The most common genotypes were HPV16 and HPV58. Conclusions: Preoperative CIN combined with VAIN and/or VIN and positive incision margin are high risk factors for HPV infection. HPV typing after LEEP plays an important role in predicting residual or recurrence of lesions.

Key words: Uterine cervical diseases, Cervix uteri, Cervical intraepithelial neoplasia, Papillomaviridae, Electrosurgery, Recurrence

ZHANG Jing，ZHANG De-yu，WANG Dan-bo. Clinical Analysis of Human Papillomavirus Infection after Loop Electrosurgical Excision Procedure for Cervical Intraepithelial Neoplasia[J]. Journal of International Obstetrics and Gynecology, 2018, 45(6): 658-661.

References

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