Abstract: High-grade cervical squamous intraepithelial lesion (HSIL) is internationally recognized as precancerous lesions of the cervix. About 17% of untreated HSIL patients are likely to develop into a invasive cancer. Therefore, accurate and standard treatment of cervical lesions, especially HSIL, is an important means to prevent cervical cancer. The American Society of Colposcopy and Cervical Pathology (ASCCP) recommends cold knife conization (CKC) and loop electrosurgical excision procedure (LEEP) as the primary methods of diagnosis and treatment. However, some patients still have the risk of residual lesions, recurrence and progression after treatment. At present, there are great differences in residual lesions, recurrence and progression after HSIL treatment, and the risk factors of residual lesions, recurrence and the mode of follow-up after HSIL treatment are still uncertain. The purpose of this article is to review the risk factors, management, follow-up and pregnancy-related issues of residual and recurrent lesions after HSIL treatment, so as to guide clinical treatment.

Key words: Squamous intraepithelial lesion, Positive margin, Residual lesion , Recurrence, Cone pregnancy