Abstract: Gynecological malignancy is a serious threat to women′s health. In recent years, with the development of technology, genetic susceptibility has been paid more and more attention in many factors affecting the development of gynecological tumors. Studies show that up to 10 percent of tumors can be attributed to genetic mutations which increases an individual′s susceptibility to certain cancers. The biggest challenge for individuals at particular risk of cancer is to develop and popularize better testing methods to detect high-risk groups in a timely manner. In this field, China started late and developed slowly and genetic screening programs have not been widely popularize to current screening program of gynecological oncology. In this review, the most common hereditary cancer syndromes in gynecological hereditary tumors, including hereditary breast-ovarian cancer syndrome, Lynch syndrome and multiple hamartoma syndrome, are reviewed from the aspects of clinical features, gene and gene detection, prevention and treatment, so as to increase people′s comprehensive understanding to hereditary cancer syndromes. This paper emphasizes that all high-risk groups should be screened for relevant genes, and clinical intervention should be implemented before the onset of disease, which can benefit patients.

Key words: Genital neoplasms, female, Genetic predisposition to disease, Hereditary breast and ovarian cancer syndrome；Colorectal neoplasms, hereditary nonpolyposis, Hamartoma syndrome, multiple, Genetic testing