Abstract: Pre-eclampsia is a pregnancy-specific disease, which is one of the important causes of maternal and perinatal deaths. The pathogenesis of pre-eclampsia has not yet been fully clarified. In recent years, studies have shown that pregnancy-related plasma protein-A (PAPP-A) and placental growth factor (PlGF) play an important role in the occurrence and development of pre-eclampsia. In the peripheral blood of patients with pre-eclampsia, the decrease of PAPP-A and PlGF results in vascular damage, inhibits the growth of placenta, further aggravates the ischemia and anoxia of placenta, promotes and aggravates the occurrence of organ dysfunction and maternal infant complications. The decrease level of PAPP-A and PlGF is also related to the severity of the disease according to the biological properties of PAPP-A, PlGF and their expression level in maternal serum, they can be used as one of the relevant indexes to predict the occurrence and development of pre-eclampsia. The data analysis indicates that the combination of them is more effective in prediction, which can provide the basis for early prevention and early treatment of pre-eclampsia.

Key words: Pre-eclampsia；, Pregnancy-associated plasma protein-A；, Placenta growth factor；, Forecasting；, Female