Abstract: Endometriosis (EMs) is a common gynecological disease. Due to the lack of sensitive and specific biological indicators in clinic, the disease can only be diagnosed by laparoscopy. It is difficult to avoid recurrence of EMs either by drug therapy or by surgery. Therefore, exploring the pathogenesis of endometriosis is of great significance to guide clinical diagnosis and treatment, alleviate clinical symptoms, improve prognosis and reduce social burden. With the development of high-throughput sequencing and gene chip technology, long non-coding RNAs (lncRNAs) molecules, as an important regulator of cell function, have attracted more and more attention in the occurrence and development of a variety of chronic diseases. The article summarizes the expression pattern and mechanism of some popular lncRNAs in EMs in recent years, and discusses the feasibility of using many kinds of lncRNAs molecules as diagnostic and therapeutic targets for EMs. In addition, the article also points out that lncRNAs may mediate the association between autoimmune diseases and EMs, which provides a new idea for exploring the physiological and pathological process and treatment direction of EMs.

Key words: RNA, long noncoding；, RNA, untranslated；, Endometriosis；, Autoimmune diseases；, Gene regulatory networks