Abstract: Objective: To evaluate the effect of spirolactone on patients with premenstrual syndrome （PMS）. Methods: A total of 60 subjects were randomly divided into the spirolactone（treatment）and vitamin B6（control）, with 30 subjects in each group. Scale of SAS and SDS were used to evaluate the severity of the anxiety and depression. Plasma aldosterone, sodion, potassiumion and 24 hrs urine volumes were measured to compare the degree of fluid retention. Results: There was no significant difference of all the indexes between the two groups before treatment. SAS score in the spirolactone group was significantly lower than that in the control group after the treatment（P ＜0.05）, but not for the SDS score. There was significant difference of plasma aldosterone，sodion, and urine volume, between the two groups after treatment（P ＜0.05 or P ＜0.01）. There was no significant difference of the change of plasma potassium level between the two groups. Conclusions: Spirolactone was more effective in improvement of the anxiety and water-sodium retention for PMS than that of vitamin B6.

Key words: Premenstrual syndrome, Spironolactone, Vitamin B6, Anxiety, Depression