Abstract: Visfatin is a newly discovered novel adipocytokine, that mainly distributions in the fat cells of the nucleus and the cytoplasm. It can regulate the differentiation and adipogenic effect of visceral fat cells and insulin sensitivity. It has been confirmed that ovarian granulosa cells secrete visfatin, which can be affected by certain hormones. Polycystic ovary syndrome is an endocrine and metabolic disorders that seriously impacts on female reproductive. Its main clinical features are insulin resistance, over-weight and the reproductive endocrine and metabolic abnormalities. That makes visfatin closely linked to the pathogenesis of polycystic ovary syndrome. Related researches between visfatin and polycystic ovary syndrome are summarized as following.

Key words: Polycystic ovary syndrome, Insulin resistance, Follicular fluid, Visfatin, Granulosa cells