Mechanism of Angiotensin Ⅱ and Its Type 1 Receptor Blockers in Ovarian Cancer

doi:10.12280/gjfckx.20210248

Abstract

Abstract:

Ovarian cancer is one of the most common malignant tumors in the female reproductive system. Because of its insidious onset, most patients are already in advanced stage when they have symptoms, and are prone to metastasis and recurrence. The mortality rate of ovarian cancer ranks first among gynecological malignant tumors. Therefore, it is very important to further explore the mechanism of ovarian cancer and find potential therapeutic targets. AngiotensinⅡ(AngⅡ) is the most bioactive factor in renin-angiotensin system (RAS), mainly involved in the regulation of metabolism of the body′s blood pressure and salt water. At present, some studies found that it combined with the angiotensin type 1 receptor (AT1R) to activated related pathways and that is closely related to the process of the occurrence and development of ovarian cancer and metastasis. And AT1R antagonists angiotensin receptor blocker (ARB) can selectively bind to AT1R blocking AngⅡ-AT1R pathways, thereby blocking or inhibit AngⅡrole in ovarian cancer. Further study on the mechanism of AngⅡand its type 1 receptor antagonist in ovarian cancer may provide evidence for new therapeutic targets for ovarian cancer.

Key words: Ovarian neoplasms, Angiotensin Ⅱ, Receptor,angiotensin,type 1, Angiotensin Ⅱ, type 1 receptor blockers

GONG Li-ping, SUN Li-tao, TIAN Jia-wei. Mechanism of Angiotensin Ⅱ and Its Type 1 Receptor Blockers in Ovarian Cancer[J]. Journal of International Obstetrics and Gynecology, 2022, 49(1): 24-28.

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