Advances in Diagnosis and Treatment of Ovarian Granulosa Cell Tumor

doi:10.12280/gjfckx.20220471

Abstract

Abstract:

Ovarian granulosa cell tumor (OGCT) is a rare neoplasia of sex-cord stromal origin and accounts for 2%-5% of ovarian tumors. It can be divided into adult granulosa cell tumor (AGCT) and juvenile granulosa cell tumor (JGCT) according to the histopathological characteristics. Due to its secretion function, it often presents estrogen stimulation symptom. Mutation of FOXL2 gene c.402C→G is the most important pathogenic factor in AGCT and a molecular diagnostic marker. Surgery is the first choice for OGCT. The most important factor affecting the prognosis of patients is clinical stage. Inhibin β and AMH can be used as serological markers in diagnosis and detection of OGCT. OGCT generally has a favorable prognosis. Due to the characteristics of long-term recurrence, long-term follow-up should be insisted.

Key words: Ovarian neoplasms, Granular cell tumor, Forkhead transcription factors, Therapy

ZHOU Li, QU Peng-peng. Advances in Diagnosis and Treatment of Ovarian Granulosa Cell Tumor[J]. Journal of International Obstetrics and Gynecology, 2022, 49(6): 630-634.

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