Prognostic Indicators of Ovarian Cancer in Immunotherapy

doi:10.12280/gjfckx.20220206

Abstract

Abstract:

Ovarian cancer has its own immunogenicity and can be recognized and attacked by the host immune system, which plays a very important role in the pathogenesis and disease progress of ovarian cancer. In recent years, drugs such as poly- adenosine diphosphate polymerase inhibitors, anti-angiogenesis drugs and targeted homologous recombination defects have been widely used in the maintenance treatment of ovarian cancer. These drugs have greatly improved the prognosis of patients, significantly improved the survival time of ovarian cancer patients, and delayed the recurrence. With the continuous application of immunotherapy in clinic, it is extremely important to explore the relevant predictive indicators that can be used to evaluate the prognosis of ovarian cancer immunotherapy. Effective and convenient prognostic indicators can provide reference for clinicians′ diagnosis, treatment and decision-making. At present, it is still one of the difficulties to evaluate the prognostic indicators of ovarian cancer. This paper reviews the predictive value of immune score, programmed cell death receptor 1, neutrophil-to-lymphocyte ratio, bone marrow-derived suppressor cells and other indicators in the prognosis of ovarian cancer immunotherapy.

Key words: Ovarian neoplasms, Immunotherapy, Prognosis, Programmed cell death receptor 1, Immunoscore

QU Xing, HAN Feng-jiao, MA Li, WANG Xiao-hui. Prognostic Indicators of Ovarian Cancer in Immunotherapy[J]. Journal of International Obstetrics and Gynecology, 2022, 49(6): 626-629.

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