Research Progress on the Regulatory Mechanism of Autophagy on Ovarian Microenvironment

doi:10.12280/gjfckx.20220856

Abstract

Abstract:

Autophagy is a cell survival pathway that assists in reproductive development, immune regulation, degradation metabolism and cell aging, and plays a key role in maintaining homeostasis. Recent studies have pointed out that autophagy not only participates in the growth, development and atresia of follicles, but also regulates the function of ovarian stroma and corpus luteum to a certain extent. It also abnormally regulates ovarian microenvironmental status, inducing various pathologies such as ovarian polycystic-like changes, ovarian aging and ovarian tumor. At the same time, the immune imbalance caused by the degeneration of the ovarian microenvironment will also react on the autophagosomes, resulting in a vicious cycle of microecology. The role of autophagy in the ovary is reviewed to lay the foundation for the clinical treatment of autophagy-related reproductive disorders and ovarian diseases.

Key words: Autophagy, Follicular atresia, Polycystic ovary syndrome, Premature ovarian insufficiency, Ovarian neoplasms

ZHANG Yu-lin, FENG Xiao-ling. Research Progress on the Regulatory Mechanism of Autophagy on Ovarian Microenvironment[J]. Journal of International Obstetrics and Gynecology, 2023, 50(3): 337-342.

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