Abstract: Pelvic inflammatory disease （PID）is a serious and costly　common disease for reproductive women. Studying an appropriate animal model will be useful for ascertaining its pathogenesis, selection and evaluation of anti-inflammatory medicines，and potential vaccine candidates. Until now, there are many methods for the PID animal models. However，the models have some limitations. It is needed further study afterwards. This article focuses on the establishiment and application of animal model in PID.

Key words: Pelvic inflammatory disease, Disease models, animal, Chlamydiaceae infections, Neisseria gonorrhoeae, Mycoplasma