Abstract: Sulfonation is an important reaction in the metabolism of numerous exogenous and endogenous compounds. A supergene family of enzymes called sulfotransferases（SULTs）catalyze this reaction. In humans four SULT families，SULT1，SULT2，SULT4 and SULT6，have been identified that containning at least thirteen distinct members. Part of the SULT family members involved in metabolism of sex hormones sulfation. Research indicated abnormal SULT1A1 and SULT1E1 gene expression in uterine fibroids,endometrial cancer and other gynecological tumors and recent studies have begun to suggest roles of SULT1A1 and SULT1E1 polymorphism acting in gynecological tumors susceptibility.

Key words: Catalysis, Genes, Genital neoplasms, female, Polymorphism, single nucleotide