Abstract: Hypoxia inducible factor-1alpha（HIF-1α） is a major transcription factor that widely exists in mammal and human body in case of hypoxia. HIF-1α activates target genes to transcript and makes the organisms to adapt the hypoxic microenvionment. Also it plays key roles in tumor angiogenesis. Vascular endothelial growth factor（VEGF） is an important target gene of HIF-1α and the receptor KDR is a crucial receptor of VEGF. In recent years a large amount of studies indicate that HIF-1α, VEGF, KDR proteins in a variety of tumors shows high expression and positively associated with each other. Here we make a review of HIF-1α, VEGF, KDR for their molecular biology, their functions in tumor functions and the reseach progress in gynecological tumors.

Key words: Hypoxia-inducible factor 1, Vascular endothelial growth factors, Receptors, vascular endothelial growth factor, Genital neoplasms, femal