Abstract: Objective：To investigate the association between the Obestatin levels in maternal periphery or cord blood and maternal or neonatal body index. Methods：30 obese pregnant women in Obstetrics and Gynecology Department of Affiliated Hospital of Logistical College of Chinese People′s Armed Police Force from August 2013 to September 2014 were chose as the obese group and other 35 normal weight pregnant women were chose as the contro1 group. The venous blood sample was collected in later pregnancy and cord blood sample in parturient period was gathered. ELISA was used to detect serum Obestatin level in maternal periphery and cord blood. Meanwhile, body mass index (BMI) in pregnant women was recorded, and new birth weight was recorded after birth. The LANGE skinfold caliper was used to measure the neonatal subscapular skinfold thickness, thigh skinfold thickness, suprailiac skinfold thickness, triceps skinfold thickness and hypodermic fat thickness of abdomen within 24 hours after birth. Results：Compared with control group, the obestatin levels of maternal periphery or cord blood in the obese group were statistically significant decreased（t＝16.707，P＝0.000）. There was a negative relationship between obestatin level in maternal periphery and BMI in obese pregnant women（r=-0.898，P＝0.000）, and there was a negative relationship between Obestatin level in cord blood and antepartum weight and hypodermic fat thickness of abdomen（r=-0.789，P＝0.000；r=-0.840，P＝0.018）. Conclusions： There is relation between maternal periphery Obestatin level and body index, and there is relation between cord blood Obestatin level and antepartum body index in obese pregnant women.

Key words: Obesity, Pregnant women, Body mass index, Fetal blood, Obestatin