Abstract: The cervical cancer is one of the common gynecologic malignant tumors，and in recent years the amount of the young patients has obviously risen. The cervical intraepithelial neoplasia（CIN）is closely related to cervical invasive carcinoma as a group of precancerous lesions，which is also an important stage in the cervical cancer progression. The proceeding from cervical intraepithelial neoplasia（CIN）to cervical cancer is a long period，so the effective diagnosis and treatments of CIN are the best way to prevent the cervical cancer. Some studies claimed that CK17 was a marker of the cervical stem cells and reflected the phenomena from immature to mature of cervical cell metaplasia. The expression level of CK8 and CK17 is related to the degree of CIN and cervical cancer. Analysis the expression level of CK8，CK17 can be as a predictor for the high-risk cases.The P16INK4a ′s abnormal methylation is related to the the clinical stages and pathological classification of cervical cancer. In terminal and high malignant degree′s tissues，its activities is obviously enhanced. This review will discuss the advances of cytokeratins and P16INK4a in the cervical cancer and CIN in terms of occurrence and development .

Key words: Cervical intraepithelial neoplasia, Uterine cervical neoplasms, Keratins, P16INK4a