半乳糖凝集素在妊娠期的表达

doi:10.12280/gjfckx.20200706

摘要/Abstract

摘要：

半乳糖凝集素是一个系统学上保守的凝集素家族,可与β-半乳糖苷特异结合,由15种不同的类型组成,每种类型都有特定的功能。在人类发现的13种半乳糖凝集素中,7种在胎盘中表达,调节免疫和发育。半乳糖凝集素通过调节妊娠早期滋养层细胞的发育、迁移和侵袭而促进胎盘形成。此外,半乳糖凝集素是调节母体对胚胎免疫耐受的关键因子。近年来,半乳糖凝集素在妊娠相关过程中发挥的作用已引起人们的重视,其表达改变与异常妊娠和不孕有关。综述近年来半乳糖凝集素在支持孕妇适应妊娠和胎盘发育中的作用、其失调对疾病发展的影响以及在不良妊娠结局的诊断和治疗干预中的应用。

关键词: 半乳糖凝集素类, 妊娠, 胎盘, 免疫耐受, 先兆子痫

Abstract:

Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Of the 13 galectins found in humans, 7 are expressed in the placenta and regulate immunity and development. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in pregnancy-associated process has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses its relevance as potential therapeutic targets in pregnancy disorders.

Key words: Galectins, Pregnancy, Placenta, Immune tolerance, Pre-eclampsia

赵童童, 孙礼强, 邵丹卉, 穆文玉, 韩秋峪. 半乳糖凝集素在妊娠期的表达[J]. 国际妇产科学杂志, 2021, 48(3): 251-254.

ZHAO Tong-tong, SUN Li-qiang, SHAO Dan-hui, MU Wen-yu, HAN Qiu-yu. Expression of Galectins in Pregnancy[J]. Journal of International Obstetrics and Gynecology, 2021, 48(3): 251-254.

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