NLR家族Pyrin域蛋白3炎症小体与妊娠的研究进展

doi:10.12280/gjfckx.20200965

摘要/Abstract

摘要：

炎症小体是人类天然免疫系统的重要组成部分,参与包括妊娠在内的多种炎症反应,其中NLR家族Pyrin域蛋白3（NLRP3）炎症小体是目前研究最广泛的炎症小体,是宿主防御反应的重要因素,其能够对固有免疫进行调控,各种环境剌激物、多种微生物、内源性或外源性危险信号、病原体和不同的病原相关分子模式（PAMPs）/损伤相关分子模式（DAMPs）都可以激活NLRP3炎症小体释放细胞因子,诱导半胱氨酸天冬氨酸蛋白酶1（caspase-1）依赖的程序性细胞死亡（细胞焦亡）,参与多种炎性疾病过程,但对其调控机制尚不明确。近年研究发现NLRP3炎症小体与分娩的发动机制有关,妊娠期间启动了NLRP3炎症小体介导的免疫反应,并且NLRP3炎症小体表达异常与复发性流产、早产、子痫前期和妊娠期糖尿病等妊娠期疾病的发生、发展有关。现就NLRP3炎症小体与妊娠的研究进展进行综述。

关键词: NLR家族,热蛋白结构域包含蛋白3, 炎性体, 分娩, 妊娠, 糖尿病,妊娠, 先兆子痫, 早产, 流产,习惯性

Abstract:

Inflammasome are an important part of the natural immune system and participate in many inflammatory reactions including pregnancy. NLRP3 inflammasome is the most widely studied inflammasome, which is an important factor of host defense response. It can regulate innate immunity, various environmental stimuli, various microorganisms, endogenous or exogenous danger signals, pathogens and different PAMPs/DAMPs can activate NLRP3 inflammasome to release cytokines,induce caspase-1 dependent apoptotic process,and participate in various inflammatory disease processes, but the regulatory mechanism is not clear. In recent years, it has been found that NLRP3 inflammasome is associated with the mechanism of delivery, and the NLRP3-mediated immune response is initiated during pregnancy. The abnormal expression of NLRP3 inflammasome is associated with the development of gestational diseases such as recurrent miscarriage, premature birth, preeclampsia and gestational diabetes. This article reviews the research progress of NLRP3 inflammasome and pregnancy.

Key words: NLR family,pyrin domain-containing 3 protein, Inflammasomes, Parturition, Pregnancy, Diabetes,gestational, Pre-eclampsia, Premature birth, Abortion,habitual

赵璐, 杨华, 刘国艳. NLR家族Pyrin域蛋白3炎症小体与妊娠的研究进展[J]. 国际妇产科学杂志, 2021, 48(3): 255-258.

ZHAO Lu, YANG Hua, LIU Guo-yan. Research Progress of NLRP3 Inflammasome and Pregnancy[J]. Journal of International Obstetrics and Gynecology, 2021, 48(3): 255-258.

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