国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (1): 56-59.

• 综述 • 上一篇    下一篇

炎症与妇科恶性肿瘤关系的研究进展

郑兴邦;王建六   

  1. 100044 北京大学人民医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-02-15 发布日期:2010-02-15
  • 通讯作者: 21645

he Research Progress of Ralationship Between Inflammation and Gycecological Malignancies

ZHENG Xing-bang;WANG Jian-liu   

  1. Department of Gynecology, Peking University People Hospital, Beijing 100044, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-02-15 Online:2010-02-15

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摘要： 炎症和肿瘤是人体常见病理生理反应。炎症与肿瘤发生、发展、扩散关系密切。富含炎症细胞、细胞因子、趋化因子、促DNA损伤物质的炎症微环境可诱发细胞的增殖、突变，肿瘤细胞的生长、扩散以及免疫逃避。妇科肿瘤研究也证实炎症与妇科肿瘤关系密切。对宫颈癌，卵巢癌及子宫内膜癌等常见妇科肿瘤研究均发现，炎症通过炎症细胞、炎症因子等诸多途径促进肿瘤发生进展，其中肿瘤坏死因子α（TNF-α），环氧合酶2（COX-2）及转录因子核因子κB（NF-κB）是研究较集中的环节。针对以上途径的药物，如非甾体类抗炎药（NASID）和TNF-α抑制剂已初步用于临床。对炎症和肿瘤关系的研究有助于妇科肿瘤的预防和治疗。

关键词: 炎症, 妇科恶性肿瘤, 肿瘤坏死因子, 环氧合酶2, 核因子κB

Abstract: Inflammation and cancer are common physiological responses in human body. It has been found that inflammation is closely related to the initiation, progression and metastasis of tumor .The inflammatory microenvironments rich in inflammatory cells, cytokines, chemokines and DNA damage-promoting agents may induce cell proliferation, mutation and the initiation, metastasis and immune evasion of cancer cell. Inflammation also promote the cancer initiation and progress through complex mechanism including inflammatory cells and inflammatory cytokines in gycecological malignancies such as cervical cancer, ovarian cancer and endometrial cancer. The tumor necrosis factor α （TNF-α）, cyclooxygenase-2 （COX-2） and nuclear factor-kappa B （NF-κB） may play the critical role. Nonsteroidal antiinflammatory drugs （NSAID） and TNF-α inhibitor have been used as the preventative and therapeutic drugs against the malignancies. The better understanding of mechanisms linking inflammation and cancers will be beneficial to the development of prevention and therapies of inflammation-associated cancers.
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Key words: Inflammation, Gycecological malignancies, Tumor necrosis factor alpha, Cyclooxygenase 2, Nuclear factor-kappa B