国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (3): 193-196.

• 综述 • 上一篇    下一篇

妊娠期肝内胆汁淤积症病因学研究进展

樊婷婷,赵树旺   

  1. 300270 天津市大港医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-06-15 发布日期:2011-06-15

Progress in Study on Etiology of Intrahepatic Cholestasis of Pregnancy

FAN Ting-ting，ZHAO Shu-wang   

  1. Department of Obstetrics and Gynecology，Dagang Hospital of Tianjin，Tianjin 300270，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-06-15 Online:2011-06-15

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摘要： 妊娠期肝内胆汁淤积症（ICP）为高危妊娠，是妊娠期特有疾病。临床上以妊娠中晚期母体皮肤瘙痒和血清胆汁酸升高为特征，与围生儿不良结局密切相关，ICP已逐步引起产科医师的重视。然而，ICP的病因学复杂，至今尚不完全清楚，有可能是遗传易感妇女体内生殖激素及其代谢产物造成胆汁淤积，环境因素及其他因素也有可能参与其发病，其发病原因和发病机制都有待进一步的探索和研究。

关键词: 胆汁淤积, 肝内, 妊娠并发症, 妊娠结局, 综述

Abstract: Intrahepatic cholestasis of pregnancy （ICP） is classified as high-risk pregnancy that is a pregnancy-specific disease characterized by maternal pruritus in the third trimester，raised serum bile acids and closely related to adverse fetal outcomes，hence ICP has gradually drawn attention of obstetricians. However， so far， the etiology of ICP has not been fully understood due to its complexity. The possible factors of the cholestatic effects can be reproductive hormones and their metabolites in the bodies of genetically susceptible women. Besides that，environmental factors and other factors could be involved in the pathogenesis as well. The etiology and pathogenesis of ICP are yet to be further explored.

Key words: Cholestasis, intrahepatic, Pregnancy complications, Pregnancy outcome, Review