国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (5): 458-460.

• 论著 • 上一篇    下一篇

高龄妇女体外受精-胚胎移植助孕结局分析

邓 彬,李 予,王文军,陈向红,陈玉珍,阙文清,杨冬梓, 张清学   

  1. 510120 广州,中山大学孙逸仙纪念医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 张清学

Analysis of the Outcome of in Vitro Fertilization and Embryo Transfer of Women with Advanced Age

DENG Bin，LI Yu， WANG Wen-jun， CHEN Xiang-hong， CHEN Yu-zhen， QUE Wen-qing， YANG Dong-zi， ZHANG Qing-xue.   

  1. Reproductive Medical Centre，Sun Yat-sen Memorial Hospital，Sun Yat-Sen University，Guangzhou 510120，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-10-15 Online:2011-10-15
  • Contact: ZHANG Qing-xue

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4795

被引次数

23

摘要： 目的：探讨高龄妇女接受体外受精－胚胎移植（IVF-ET）治疗后的助孕结局。方法：对2001年7月—2009年7月中山大学孙逸仙纪念医院生殖中心行IVF-ET治疗的高龄妇女（≥35岁）的753个取卵周期的临床资料进行回顾性分析。按妇女年龄分为4组：A组（35～36岁），B组（37～38岁），C组（39～40岁），D组（≥41岁），分析不同组的IVF-ET结局。结果：724个移植周期（另外29个周期无胚胎移植），97个周期获活产，活产率为13.4%。随年龄增长，获卵数明显减少，各组分别为（9.8±6.0），（8.6±5.4），（6.7±4.3），（5.3±4.4）个；胚胎种植率明显下降，分别为17.9%，12.8%，10.0%和4.3%；活产率明显下降，分别为16.7%，13.3%，12.4%和2.3%。各组上述指标差异均有统计学意义（P分别为0.001，0.001和0.006）。年龄≥43岁的45例患者中无一例获得活产。结论：随年龄增长，高龄妇女接受IVF-ET治疗后的胚胎种植率和活产率明显下降，40岁以后下降更为明显。IVF治疗是否应设定年龄上限有待进一步研究。

关键词: 受精, 体外, 胚胎移植, 妊娠结局, 年龄因素

Abstract: Objective：To observe the influence of advanced female age on the outcome of in vitro fertilization and embryo transfer（IVF-ET）. Methods：Total of 753 IVF-ET cycles of women with age ≥35 years old from July 2001 to July 2009 were analyzed. According to female age，the patients were divided into 4 groups：group A（35-36 years），group B（37-38 years），group C（39-40 years），group D（≥41 years）. Results：The live birth rate of 724 cycles with embryos transferred was 13.3%. With the increasing of age，the number of oocytes retrieved，the implantation rate and the live birth rate significantly decreased（P values were 0.001，0.001 and 0.006，respectively）. The number of oocytes retrieved were 9.8±6.0，8.6±5.4，6.7±4.3 and 5.3±4.4，respectively. The implantation rates were 17.9%，12.8%，10.0% and 4.3%，respectively. The live birth rates were 16.7%，13.3%，12.4% and 2.3%，respectively. No live birth was obtained by 45 women aged ≥43 years. Conclusions：With the age increases，the implantation rate and live birth rate of IVF-ET decrease significantly which is more obvious when the age older than 40 years. Advanced researches are needed to determine the upper limit of age for IVF.

Key words: Fertilization in vitro, Embryo transfer, Pregnancy outcome, Age factors