国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (6): 570-573.

• 综述 • 上一篇    下一篇

孕激素受体发挥作用的机制及其调控因素

刘 颖, 谢梅青   

  1. 510120 广州,中山大学孙逸仙纪念医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-12-15 发布日期:2012-12-15

The Mechanism and Regulation Factors of Progesterone Receptor Activation

LIU Ying，XIE Mei-qing   

  1. Department of Gynecology and Obstetrics，the Sun Yat-sen Memorial Hospital，Sun Yat-sun University，Guangzhou 510120，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-12-15 Online:2012-12-15

PDF (PC)

5627

被引次数

8

摘要： 孕激素受体对介导孕激素在组织中的生物学作用有重要作用，其是核转录调节因子，主要有2种亚型。在胞核内孕激素受体可调节靶基因的转录，在胞质中还能激活相关信号通路，共同调节细胞的增殖和分化。孕激素受体功能的发挥受多种因素调节，包括协同调节因子、蛋白质翻译后修饰、受体基因转录水平等，各种调控因素的变化都会影响孕激素受体功能的正常发挥，致使其对靶器官的调控失常。

关键词: 受体, 孕酮, 基因表达调控, 蛋白质生物合成, 信号传导, 转录, 遗传

Abstract: The biological action of progesterone mediates by progesterone receptor（PR） which is expressed as two isoforms，PRA and PRB. PR is a member of ligand-activated nuclear transcription regulators，and it also can active signaling pathways extra-nuclear. PR plays an important role in cell proliferation and differentiation. There are many factors regulating the activation of progesterone receptor，such as synergic regulators，post-translational modifications and gene transcription. The disorder of PR activations may lead to pathologic changes of target organs.

Key words: Receptors, progesterone, Gene expression regulation, Protein biosynthesis, Signal transduction, Transcription