国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (6): 609-612.

• 论著 • 上一篇    下一篇

天津地区大气颗粒物质与妊娠早期稽留流产的关系

侯海燕 , 陈亚琼,王 丹, 邹晓萍   

  1. 300162 天津,武警后勤学院附属医院妇产科(侯海燕,陈亚琼,邹晓萍);北京武警总医院(王 丹)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-12-15 发布日期:2012-12-15
  • 通讯作者: 陈亚琼

Association Between Ambient Air Particulate Matter and Missed Abortion in Early Pregnancy in Tianjin

HOU Hai-yan，CHEN Ya-qiong，WANG Dan，ZOU Xiao-ping   

  1. Department of Obstetrics and Gynecology，Affiliated Hospital of the Chinese People's Armed Forces Logistics College，Tianjin 300162，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-12-15 Online:2012-12-15
  • Contact: CHEN Ya-qiong

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摘要： 目的：研究天津地区空气污染中颗粒物质与妊娠早期稽留流产的关系。方法：利用回顾性病例对照研究，收集天津地区15家医院2001年1月—2006年12月稽留流产的病例资料，同期同家医院按年龄1∶1选取对照，对照组为正常妊娠要求行人工流产手术的妇女。获取天津市环境监测中心同年市内六区国控监测点空气污染物中颗粒物质（直径≤10 μm的颗粒物质、总悬浮颗粒物质）的月平均浓度（mg/m3）。妊娠不同时期空气污染物的暴露水平应用GIS模型依据每个研究对象居住地址距离最近的监测点污染物水平加以评估。结果：经过校正妊娠妇女年龄、妊娠产次后，发现围妊娠期高浓度总悬浮颗粒物质（≥0.996 mg/m3）的暴露可能会增加稽留流产发生的危险性（OR=
1.40，95%CI：1.06～1.86）。未发现妊娠前后直径≤10 μm的颗粒物质的暴露与稽留流产的发生有相关性。结论：围妊娠期暴露于相对较高浓度的大气颗粒物质可能会增加稽留流产发生的危险性。

关键词: 流产, 稽留, 空气污染物, 颗粒物, 围生医学

Abstract: Objective：To examine association between the ambient air particulate matter pollution and the missed
abortion in which the embryo dies but miscarriage has not yet occurred during early pregnancy in Tianjin. Methods：A retrospective case-control study has been conducted with focus on the pertinent cases collected from 15 hospitals located in the urban core of Tianjin from January 2001 to December 2006. These cases experience missed abortions while controls undergo selective abortions. Each case is assigned one control matched with maternal age. Monthly average concentrations of ambient air particulate matter with aerodynamic diameters ≤10 μm（PM10） and total suspended particle （TSP） from 2001 to 2006 are obtained from the monitoring network of Tianjin Environment Monitoring Center. We assign air pollution exposures from the nearest monitoring station to each individuals-based residential home address by GIS model. Results：After adjusting for maternal age，gestational week，gravidity and parity. We found that relatively higher TSP（≥0.996 mg/m3）（OR=1.40，95%CI：1.06-1.86） exposure during peri-pregnancy period increased the risk of missed abortion. There is no correlation between PM10 exposure during progestation or conception and missed abortion. Conclusions：Exposed to relatively high levels of gaseous air particulate matter during peri-pregnancy period may be associated with missed abortion.

Key words: Abortion, missed, Air pollutionts, Particulate matter, Perinatology