国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (3): 203-206.

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细胞因子信号传导抑制因子3与妊娠的研究进展

周 欣, 孙丽洲   

  1. 210029 南京医科大学第一附属医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-06-15 发布日期:2013-06-15
  • 通讯作者: 孙丽洲

The Advanced Study of SOCS3 and Pregnancy

ZHOU Xin，SUN Li-zhou   

  1. Department of Obsterics and Gynecology，First Affiliated Hospital，Nanjing Medical University，Nanjing 210029，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-06-15 Online:2013-06-15
  • Contact: SUN Li-zhou

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摘要： 细胞因子信号转导抑制因子3（SOCS3）通过调节细胞因子信号传导通路对多种细胞及细胞因子具有调节作用，是炎症和细胞凋亡的关键调节物。妊娠时母-胎单位局部微环境存在大量细胞因子，细胞因子参与妊娠期胚胎植入、胎盘形成、胎儿生长和分娩等过程，细胞因子受多方面因素精密调控，使之处于稳定状态有助于正常妊娠。SOCS3作为细胞因子信号传导调节因子参与妊娠及分娩过程，研究表明SOCS3表达异常与流产、早产、妊娠期高血压疾病和妊娠期糖尿病等妊娠疾病的发生发展有关，深入研究SOCS3在妊娠疾病中的作用，可以为妊娠相关疾病的诊断和治疗等方面提供理论依据。

关键词: 细胞因子信号转导抑制因子, 细胞因子类, 信号传导, 妊娠

Abstract: SOCS3 is the suppressor of Cytokine Signaling 3；has been characterized as a regulator in the cytokine signaling pathway，which has a role in a variety of cells and cytokines. And it is the crucial effector in inflammation and apoptosis. During pregnancy there are lots of cytokines in the maternal-fetal unit of microenvironment. Cytokines involve in embryo implantation and the formation of placenta，fetal growth，childbirth，and so on，are controlled exactly by various factors，that contain a stable state conductive to the normal pregnancy. SOCS3 as a cytokine signal transduction regulator involve in the process of pregnancy and childbirth. Abnormal expression of SOCS3 is related to the occurrence and development of miscarriages，premature delivery，gestational hypertension，gestational diabetes，and other pregnancy sickness. An in-depth study of SOCS3′s role in diseases of pregnancy has provided a theoretical basis for the pregnancy-associated disease diagnosis and treatment.

Key words: Suppressor of cytokine signaling, Cytokines, Signal transduction, Pregnancy