国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (4): 358-363.

• 综述 • 上一篇    下一篇

延时摄像在人类辅助生殖技术中的应用

石江霞, 张硕屏,龚 斐, 卢光琇, 林 戈   

  1. 410078 湖南省长沙市, 中南大学生殖与干细胞工程研究所(石江霞,张硕屏,龚 斐,卢光琇,林 戈),卫生部人类干细胞与生殖工程重点实验室(石江霞,张硕屏,龚 斐,卢光琇,林 戈),中信湘雅生殖与遗传专科医院(张硕屏,龚 斐,卢光琇,林 戈)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-08-15 发布日期:2013-08-15

Time-lapse in Human Assisted Reproductive Technology

SHI Jiang-xia, ZHANG Shuo-ping, GONG Fei, LU Guang-xiu, LIN Ge   

  1. Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha 410078, China(SHI Jiang-xia,ZHANG Shuo-ping, GONG Fei, LU Guang-xiu, LIN Ge); Key Laboratory of Stem Cell and Reproductive Engineering, Ministry of Health, Changsha 410078, China(SHI Jiang-xia, ZHANG Shuo-ping, GONG Fei, LU Guang-xiu, LIN Ge); Reproductive & Genetic Hospital of CITIC-Xiangya, 410078 Changsha, China(ZHANG Shuo-ping, GONG Fei, LU Guang-xiu, LIN Ge)
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-08-15 Online:2013-08-15

摘要: 体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)是广泛应用于不孕治疗的人类辅助生殖技术之一。由于单次促排卵治疗可以获得多个胚胎,临床上如何选择具有发育潜能的胚胎进行移植,以保证在一定临床妊娠率的前提下减少移植胚胎数目,一直是辅助生殖技术研究的一大热点。目前评价胚胎质量的方法主要是选取特定的时间点观察胚胎,依据形态学指标对胚胎质量进行评估。而近年来出现的胚胎延时摄像技术(time-lapse)能够对胚胎体外发育过程进行全程监控,获取胚胎发育的动态信息,建立胚胎行为学指标从而更有效地评估胚胎的发育潜能。延时摄像技术在临床上的应用优势正在逐渐彰显。

关键词: 延时摄像, 诊断显像, 胚胎发育, 受精, 体外, 胚胎移植, 囊胚, 胚胎植入

Abstract: One of the most extensively used methods in human assisted reproductive technology(ART) is in vitro fertilization-embryo transfer(IVF-ET). Due to the multiple embryos obtained per ovulation induction treatment,how to select the most potential embryo for clinical transfer in order to guarantee clinical pregnancy rate and simultaneously reduce the number of transferred embryos remains the hotspot in ART area. At present,embryo evaluation is based on morphology,which is static. The newly developed time-lapse technology is available to monitor the whole development process so as to more precisely evaluate the embryo quality. And its advantages are gradually manifested.

Key words: Time-lapse, Diagnostic imaging, Embryonic development, Fertilization in vitro, Embryo transfer, Blastula