国际妇产科学杂志

国际妇产科学杂志 ›› 2017, Vol. 44 ›› Issue (1): 118-120.

• 论著 • 上一篇    

抗苗勒管激素与非肥胖型多囊卵巢综合征合并胰岛素抵抗的关系

周伟伟1,李霞2   

  1. 1. 上海交通大学附属同仁医院
    2. 上海交通大学医学院附属同仁医院
  • 收稿日期:2016-07-13 修回日期:2016-11-15 出版日期:2017-02-15 发布日期:2017-03-28
  • 通讯作者: 李霞 E-mail:lichangjinglixia@sina.com

Association between anti-Mullerian hormone and insulin resistance in patients with polycystic ovary syndrome

周 伟伟1,   

  • Received:2016-07-13 Revised:2016-11-15 Published:2017-02-15 Online:2017-03-28

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摘要： 【摘要】目的：探究抗苗勒管激素（anti-Mullerian hormone, AMH）与非肥胖型多囊卵巢综合征（polycystic ovary syndrome, PCOS）合并胰岛素抵抗(insulin resistance, IR)的关系。方法：研究纳入102名非肥胖型PCOS患者作为PCOS组，其中胰岛素抵抗组（PCOS with IR, n=48）, 非胰岛素抵抗组（PCOS without IR, n=54），以及年龄和体重指数配对的50名非肥胖型健康人作为对照组。比较三组血清AMH水平以及AMH与PCOS合并IR的关系。结果：PCOS合并IR组血清AMH水平及HOMA-IR显著高于PCOS非合并IR组和对照组，（p<0.05）。AMH升高与PCOS合并IR相关（r1=0.683, r2=0.690, p<0.05）。结论：非肥胖型PCOS患者合并IR血清AMH水平升高，AMH升高与PCOS合并IR相关。

关键词: 多囊卵巢综合征, 抗苗勒管激素, 胰岛素抵抗

Abstract: 【Abstract】Objective: To study relationship of the anti-Mullerian hormone (AMH) and and insulin resistance (IR) in non-obese women with polycystic ovary syndrome (PCOS). Methods: The study enrolled 102 non-obese women with PCOS, in which insulin resistance group (PCOS with IR, n = 48), non-insulin-resistant group (PCOS without IR, n = 54), and the age and body mass index matched 50 non-obese healthy people as a control group. the three groups of c and the relationship between AMH and PCOS with IR. Results: Serum AMH levels and HOMA-IR in PCOS with IR group were significantly higher than PCOS with IR and control group, (p <0.05). Conclusion: Elevated serum AMH levels were found in non-obese PCOS with IR patients, AMH may be associated with PCOS with IR. 【Key words】Polycystic ovary syndrome, anti-Mullerian hormone, insulin resistance