国际妇产科学杂志 ›› 2017, Vol. 44 ›› Issue (1): 13-17.

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老年卵巢癌的治疗策略

成思蓉1,史小荣2,李爽1   

  1. 1. 山西医科大学第一临床医学院
    2. 山西医科大学第一医院
  • 收稿日期:2016-09-01 修回日期:2016-11-17 出版日期:2017-02-15 发布日期:2017-03-28
  • 通讯作者: 史小荣 E-mail:shixiaorong135@163.com

Therapy for Elderly Patients With Ovarian Cancer.

  • Received:2016-09-01 Revised:2016-11-17 Published:2017-02-15 Online:2017-03-28

摘要: 老年卵巢癌是年龄大于65岁女性的卵巢癌。近半数(45%)的患者在诊断时大于64岁[1]。随着人口老龄化和人均寿命的提高,老年卵巢癌患者的比例将会进一步提高,由于毒副反应,老年患者多不能接受最大程度的肿瘤细胞减灭术和以铂类为基础的联合化疗,因此老年卵巢癌的生存率却没有相应的提高甚至是下降。对大部分老年卵巢癌患者实施满意的减瘤术以及铂类为基础的联合化疗是可行的。为了提供最佳的治疗方案,治疗前的评估是必要的。另外,对老年卵巢癌患者进行前瞻性研究是必要的,为他们是否能从治疗中获益提供证据。

关键词: 卵巢癌, 老年, 肿瘤细胞减灭术, 化疗, 治疗前评估

Abstract: Epithelial ovarian cancer is a cancer of older women. Close to half (45%) of women diagnosed with ovarian cancer will be older than age 64. This ratio is expected to increase in the coming decades as our population ages and life-expectancy improves, while Older women with ovarian cancer receive less surgery and chemotherapy, suffer worse toxicity from surgery and chemotherapy,and have worse survival. The majority of elderly patients are able to tolerate the standard of care for ovarian cancer including initial surgical cytoreduction followed by platinum and taxane chemotherapy. To offer optimal radical management,Pretreatment assessment is needed. Large prospective clinical trials involving elderly ovarian cancer patients are warranted to offer justified evidenced based optimal treatment for those who will be benefited from the treatment.

Key words: Ovarian cancer, Elderly, Surgical cytoreduction, Chemotherapy, Pretreatment assessment