关键词: EGFR信号通路, 卵巢癌, 自噬

Abstract: 【Abstract】EGFR is the epidermal growth factor receptor, and its downstream signaling pathways affect many physiological activities of cells, including the regulation of autophagy. Autophagy is a process of cell self digestion, which is not only the self protection mechanism of cells under adverse conditions, but also can induce cell death and drug resistance. In ovarian cancer cells, EGFR-Ras-Raf-JNK, EGFR-PI3k-Akt-mTOR, and EGFR-JAK-STAT3 three pathways both promote and inhibit activation of autophagy. In recent years, EGFR inhibitors attempt to block the EGFR signaling pathways and inhibit autophagy activity and reverse drug resistance. The aim of this review is to illustrate the regulatory role of EGFR three main signaling pathways in the regulation of autophagy in ovarian cancer cells, and to provide a new target for ovarian cancer therapy and anti-drug resistance.

Key words: EGFR signaling pathway, ovarian cancer cell, autophagy