关键词: 氧化性应激, 胎盘, 活性氧, 自噬, 先兆子痫, 滋养细胞

Abstract: Oxidative stress is not only the imbalance between the generation of oxidants and the antioxidant defense system, but also the cause of various cell dysfunction and tissue damage. Oxidative stress related factors play an important role in a variety of diseases. It adjusts the homeostasis of intracellular environment through a variety of pathways. In recent years, studies have found that oxidative stress and the related oxidative damage is the main factor leading to many diseases. Indicators related to oxidative stress in pregnancy-specific diseases such as preeclampsia pregnancy and fetal growth restriction are highly expressed in maternal serum and trophoblast cells. Meanwhile, oxidative stress is involved in the pathogenesis of various chronic disorders such as cancer and hypertension. Oxidative stress, as a common pathway of pregnancy-specific diseases, has been deeply studied, among which the effect of oxidative stress on placental function has attracted much attention. This paper analyzes and summarizes the relationship between placenta and pregnancy-related diseases under different hypoxic conditions, to explore whether oxidative stress related factors have predictive effect for pregnancy-related disease prevention and treatment.

Key words: Oxidative stress, Placenta, Reactive oxygen species, Autophagy, Pre-eclampsia, Trophoblast cells