关键词: 肿瘤坏死因子α, TNF相关凋亡诱导配体, 受体, TNF相关凋亡诱导配体, 宫颈肿瘤, 细胞凋亡

Abstract: Cervical cancer is one of the most common malignancies of the female reproductive system. At present，in addition that operation, radiotherapy and chemotherapy were used to treat the cancer, oncobiology therapeutic methods are getting more and more important. Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) is one of the newly discovered tumor necrosis factor super family members. It binds to specific receptors on the surface of the cytomembrane. Through activation of caspase or mitochondrial dependent pathway, tumor cells were selectively induced to apoptosis and normal cells could escape. This property makes it considered as a potential target therapeutic factor in oncotherapy. It has extremely important clinical value. Studies found that TRAIL and its receptors were abnormally expressed in cervical cancer tissue, which has become the research hotspot in recent years. Therefore, this article reviews the structure and biological function of TRAIL and TRAIL receptors, their expression in cervical cancer epithelial cells and the research progress.

Key words: Tumor necrosis factor-alpha, TNF-related apoptosis-inducing ligand, Receptors, TNF-related apoptosis-inducing ligand, Uterine cervical neoplasms；Apoptosis