干细胞外泌体在妇科疾病中的临床应用

doi:10.12280/gjfckx.20230955

国际妇产科学杂志 ›› 2024, Vol. 51 ›› Issue (3): 279-283.doi: 10.12280/gjfckx.20230955

• 普通妇科疾病及相关研究:综述 • 上一篇下一篇

干细胞外泌体在妇科疾病中的临床应用

郭世为, 孙静莉^△(), 陈震宇, 刘森

110003 沈阳，北部战区总医院大连医科大学研究生培养基地（郭世为）;北部战区总医院和平院区妇产科（孙静莉，陈震宇）;北部战区总医院锦州医科大学研究生培养基地（刘森）

收稿日期:2023-11-26 出版日期:2024-06-15 发布日期:2024-06-25
通讯作者: 孙静莉 E-mail:zg3416@sina.com
作者简介:^△审校者

Clinical Application of Stem Cell-Derived Exosomes in Gynecological Diseases

GUO Shi-wei, SUN Jing-li^△(), CHEN Zhen-yu, LIU Sen

Graduate Training Base, Dalian Medical University, Northern Theater General Hospital, Shenyang 110003, China (GUO Shi-wei); Department of Obstetrics and Gynecology, Heping Branch, Northern Theater General Hospital, Shenyang 110003, China (SUN Jing-li, CHEN Zhen-yu); Graduate Training Base, Jinzhou Medical University, Northern Theater General Hospital, Shenyang 110003, China (LIU Sen)

Received:2023-11-26 Published:2024-06-15 Online:2024-06-25
Contact: SUN Jing-li E-mail:zg3416@sina.com

摘要/Abstract

摘要：

干细胞外泌体（stem cell-derived exosome，SC-Exo）是从干细胞中释放的一种微小囊泡，不同细胞或组织来源的外泌体在疾病的发生发展过程中起到不同的作用，已在临床各领域取得重要的成果和进展，其在复发性流产、多囊卵巢综合征、卵巢功能减退、宫腔粘连、阴道手术创面修复、妇科肿瘤和盆底功能障碍等妇科疾病中的应用价值正不断被发掘。SC-Exo可通过释放核酸、蛋白质、脂质和细胞因子等多种生物活性分子，介导靶向细胞间的信号传递及遗传信息的功能转移，对妇科相关疾病的治疗具有潜在的益处，是一种新颖而有前途的治疗策略。

关键词: 干细胞, 外泌体, 生殖器疾病, 女（雌）性, 间质干细胞, 微RNAs

Abstract:

Stem cell-derived exosomes (SC-Exo) are petite vesicles, released from stem cells. Exosomes originating from different cells or tissues play diverse roles in the pathogenesis and progression of diseases, and have made significant achievements and progress in various clinical fields. The application value of SC-Exo in gynecological diseases such as recurrent spontaneous abortion, polycystic ovary syndrome, premature ovarian insufficiency, intrauterine adhesions, wound repair in vaginal surgery, gynecological tumors and pelvic floor dysfunction is increasingly being recognized. SC-Exo can mediate the signaling and functional transfer of genetic information between targeted cells by releasing a variety of bioactive molecules such as nucleic acids, proteins, lipids and cytokines. It has potential benefits for the treatment of gynecological diseases and is a novel and promising therapeutic strategy.

Key words: Stem cells, Exosomes, Genital diseases, female, Mesenchymal stem cells, MicroRNAs

郭世为, 孙静莉, 陈震宇, 刘森. 干细胞外泌体在妇科疾病中的临床应用[J]. 国际妇产科学杂志, 2024, 51(3): 279-283.

GUO Shi-wei, SUN Jing-li, CHEN Zhen-yu, LIU Sen. Clinical Application of Stem Cell-Derived Exosomes in Gynecological Diseases[J]. Journal of International Obstetrics and Gynecology, 2024, 51(3): 279-283.

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干细胞外泌体在妇科疾病中的临床应用

Clinical Application of Stem Cell-Derived Exosomes in Gynecological Diseases

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