高雄激素诱导多囊卵巢综合征神经内分泌紊乱的研究进展

doi:10.12280/gjfckx.20240683

国际妇产科学杂志 ›› 2024, Vol. 51 ›› Issue (6): 698-702.doi: 10.12280/gjfckx.20240683

• 普通妇科疾病及相关研究:综述 • 上一篇下一篇

高雄激素诱导多囊卵巢综合征神经内分泌紊乱的研究进展

李晨曦, 范梦笑, 吴林玲^△(), 窦真, 贾佳, 孙娅瑄

300381 天津中医药大学第一附属医院，国家中医针灸临床医学研究中心生殖医学科（李晨曦，吴林玲，窦真，贾佳，孙娅瑄）；包头市蒙医中医医院产科（范梦笑）

收稿日期:2024-07-31 出版日期:2024-12-15 发布日期:2024-12-16
通讯作者: 吴林玲，E-mail：154384118@qq.com
作者简介:^△审校者
基金资助:
国家自然科学基金面上项目(82474562);天津中医药大学第一附属医院“拓新工程”基金(院ZD202104)

Advances in Research on Neuroendocrine Disorders Induced by Hyperandrogenism in Polycystic Ovary Syndrome

LI Chen-xi, FAN Meng-xiao, WU Lin-ling^△(), DOU Zhen, JIA Jia, SUN Ya-xuan

Department of Reproductive Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China (LI Chen-xi, WU Lin-ling, DOU Zhen, JIA Jia, SUN Ya-xuan); Department of Obstetrics, Baotou Mongolian Medicine and Traditional Chinese Medicine Hospital, Baotou 014040, Inner Mongolia, China (FAN Meng-xiao)

Received:2024-07-31 Published:2024-12-15 Online:2024-12-16
Contact: WU Lin-ling, E-mail: 154384118@qq.com

摘要/Abstract

摘要：

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是一种影响育龄期女性最常见的内分泌疾病，在全球范围内具有较高的发病率，其影响的生命跨度可从青春期到绝经期，以高雄激素血症、排卵障碍、多囊样卵巢为特征。尽管PCOS发病机制目前尚未完全阐明，但越来越多的研究发现中枢神经内分泌系统在PCOS的病理生理学中起着重要作用。高雄激素干扰促性腺激素释放激素（gonadotropin-releasing hormone，GnRH）神经元的活动，影响性腺类固醇激素的反馈调节，导致中枢神经系统调控生殖功能的下丘脑-垂体-性腺（hypothalamic-pituitary-gonadal，HPG）轴功能受损，成为PCOS发病的重要机制之一。综述高雄激素诱导PCOS神经内分泌紊乱的机制，并探讨这一病理过程在PCOS发生发展中的机制，以及未来研究的可能方向，以期为进一步揭示PCOS的发病机制和开发新的治疗方法提供科学依据。

关键词: 多囊卵巢综合征, 雄激素类, 神经分泌系统, 促性腺素释放激素, 下丘脑漏斗核

Abstract:

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age, with a high global prevalence. Its impact spans from puberty to menopause, characterized by hyperandrogenemia, ovulatory disorders, and polycystic ovary. Although the pathogenesis of PCOS is not yet fully understood, the central neuroendocrine system plays a significant role in the pathophysiology of PCOS indicated by many studies. One of the important mechanisms developing PCOS is below. High levels of androgens interfere with the activity of gonadotropin-releasing hormone (GnRH) neurons, and affect the feedback regulation of gonadal steroid hormones, leads to dysfunction of the hypothalamic-pituitary-gonadal (HPG) axis that regulates reproductive function in the central nervous system. This article reviewed how hyperandrogenemia induces neuroendocrine disorders in PCOS and explored the potential directions of future researches. It is hoped to provide a scientific basis for further revealing the pathogenesis of PCOS and developing new therapeutic approaches.

Key words: Polycystic ovary syndrome, Androgens, Neurosecretory systems, Gonadotropin-releasing hormone, Arcuate nucleus of hypothalamus

李晨曦, 范梦笑, 吴林玲, 窦真, 贾佳, 孙娅瑄. 高雄激素诱导多囊卵巢综合征神经内分泌紊乱的研究进展[J]. 国际妇产科学杂志, 2024, 51(6): 698-702.

LI Chen-xi, FAN Meng-xiao, WU Lin-ling, DOU Zhen, JIA Jia, SUN Ya-xuan. Advances in Research on Neuroendocrine Disorders Induced by Hyperandrogenism in Polycystic Ovary Syndrome[J]. Journal of International Obstetrics and Gynecology, 2024, 51(6): 698-702.

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高雄激素诱导多囊卵巢综合征神经内分泌紊乱的研究进展

Advances in Research on Neuroendocrine Disorders Induced by Hyperandrogenism in Polycystic Ovary Syndrome

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