核因子κB在子痫前期发病机制中的研究进展

doi:10.12280/gjfckx.20210595

摘要/Abstract

摘要：

子痫前期是孕产妇致病和死亡的主要原因之一,其发病机制可能与子宫螺旋小动脉重铸不足、炎症免疫过度激活和血管内皮细胞受损等因素有关。近期研究表明,胎盘来源的微粒（microparticle）可增加子痫前期患者血清中核因子κB（nuclear factor- kappaB,NF-κB）的表达,并促进中性粒细胞外诱捕网（neutrophil extracellular trap,NET）形成,从而引起母胎界面的炎症反应与血管内皮细胞功能障碍,参与子痫前期的病理生理过程。

关键词: 先兆子痫, NF-κB, 细胞源性微粒, 炎症, 胞外诱捕网

Abstract:

Pre-eclampsia is one of the main causes of maternal morbidity in the world. At present, it may be related to insufficient recasting of uterine spiral arterioles, excessive activation of inflammation and immunity, damage of endothelial vascular cells, and so on. Recent studies have shown that microparticle can increase the expression of NF-κB in patients with pre-eclampsia, and promote the formation of neutrophil extracellular trap, resulting in inflammation at the maternal-fetal interface and vascular endothelial cell dysfunction, and participate in the pathophysiological process of pre-eclampsia.

Key words: Pre-eclampsia, NF-kappa B, Cell-derived microparticles, Inflammation, Extracellular traps

赵钰林, 王永红. 核因子κB在子痫前期发病机制中的研究进展[J]. 国际妇产科学杂志, 2022, 49(1): 56-59.

ZHAO Yu-lin, WANG Yong-hong. Research Progress of NF-κB in the Pathogenesis of Pre-Eclampsia[J]. Journal of International Obstetrics and Gynecology, 2022, 49(1): 56-59.

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