ATP柠檬酸裂解酶在复发性流产中作用的研究进展

doi:10.12280/gjfckx.20250333

摘要/Abstract

摘要：

复发性流产（recurrent spontaneous abortion，RSA）是一种妊娠并发症，其发生与免疫功能异常、解剖结构异常、染色体异常、内分泌异常等许多因素有关，已有一些靶向药物在治疗RSA上取得了一定疗效。研究表明，ATP柠檬酸裂解酶（ATP citrate lyase，ACLY）可通过细胞内糖代谢、脂代谢等代谢途径影响细胞增殖及功能，也可通过组蛋白乙酰化介导相关细胞因子表达，进而影响免疫细胞增殖及免疫调控，并参与表观遗传调控。综述了ACLY在RSA中的潜在作用机制，以期为RSA的靶向治疗提供新的理论依据。

关键词: ATP柠檬酸(pro-S)裂合酶, 流产, 习惯性, 免疫, 细胞, 细胞因子类, 细胞代谢

Abstract:

Recurrent spontaneous abortion (RSA) is a complication of pregnancy, and its occurrence is related to many factors, such as abnormalities immune function, anatomical structure, chromosomal abnormalities, and endocrine abnormalities. Some targeted drugs have achieved certain curative effects in the treatment of RSA. Studies have shown that ATP citrate lyase (ACLY) can affect cell proliferation and function through intracellular metabolic pathways such as glucose metabolism and lipid metabolism. It can also mediate the expression of relevant cytokines through histone acetylation, thereby influencing the proliferation of immune cells and immune regulation, and participating in epigenetic regulation. This review summarizes the potential mechanism of action of ACLY in RSA, aiming to provide new theoretical basis for the targeted therapy of RSA.

Key words: ATP citrate (pro-S)-lyase, Abortion, habitual, Immunity, cellular, Cytokines, Cell metabolism

任香凝, 李萍. ATP柠檬酸裂解酶在复发性流产中作用的研究进展[J]. 国际妇产科学杂志, 2025, 52(4): 384-388.

REN Xiang-ning, LI Ping. Research Progress on the Role of ATP Citrate Lyase in Recurrent Spontaneous Abortion[J]. Journal of International Obstetrics and Gynecology, 2025, 52(4): 384-388.

图/表 1

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细胞因子	作用细胞	发挥的作用	参考文献
IL-2，IFN-γ	Th1细胞	促炎	[20]
IL-4，IL-5， IL-6，IL-10	Th2细胞	抗炎	[20]
IL-17，IL-21， IL-22	Th17细胞	促炎	[22]
IGF-β，IL-10	Treg细胞	抗炎	[22]
IL-1β，IL-4， IL-6，IL-8， IL-10，IL-13， IFN-γ，TNF-α	子宫NK细胞	促炎/抗炎	[27,31 -32]
IL-10，TGF-β	蜕膜巨噬细胞	抗炎	[33]
IL-35	滋养细胞	免疫耐受	[34]
TNF-α，IL-1β	子宫内膜基质细胞	促炎	[35]
IL-6，IL-10	蜕膜基质细胞	抗炎	[19]

细胞因子	作用细胞	发挥的作用	参考文献
IL-2，IFN-γ	Th1细胞	促炎	[20]
IL-4，IL-5， IL-6，IL-10	Th2细胞	抗炎	[20]
IL-17，IL-21， IL-22	Th17细胞	促炎	[22]
IGF-β，IL-10	Treg细胞	抗炎	[22]
IL-1β，IL-4， IL-6，IL-8， IL-10，IL-13， IFN-γ，TNF-α	子宫NK细胞	促炎/抗炎	[27,31 -32]
IL-10，TGF-β	蜕膜巨噬细胞	抗炎	[33]
IL-35	滋养细胞	免疫耐受	[34]
TNF-α，IL-1β	子宫内膜基质细胞	促炎	[35]
IL-6，IL-10	蜕膜基质细胞	抗炎	[19]